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Complete Mississippi River Cruise

22 days with American Cruise Lines  Rating: Deluxe

Book this River Cruise Now and Save!


  • Save $1,200 per couple off select cruises. Click here for eligible departures.
  • Enjoy a free open-bar cocktail hour every evening before dinner. Click here for eligible departures.
  • Receive free shore excursions on this river cruise. Click here for eligible departures.
  • Save $400 per couple off American Cruise Lines departures when you book nine months in advance. Click here for eligible departures.
  • Receive one free hotel night before American Cruise Lines sailings when you book 9 months in advance. Click here for eligible departures.

Offers subject to change or withdrawal, availability is limited. Some discounts are not combinable.

River Cruise Itinerary
Day 1 New Orleans, LA
New Orleans is commonly referred to as the Birthplace of Jazz. There is something for everyone with this city’s history, culture and arts prevalent around every corner. The open air artist colony proudly displays local artist’s works on the iron fence in Jackson Square, while the city’s 45 museums carefully preserve the city’s rich history. Consider staying an extra day or night to enjoy this lively city.
 
Day 2 Oak Alley, LA
Once serving as an antebellum sugar cane plantation, Oak Alley Plantation is rightfully named after its most distinguishing feature, a canopy of 300 year old oak trees that form a quarter-mile path leading to the Mississippi River. Restored to its 19th Century grandeur, this classic Greek revival-style antebellum mansion is purely breathtaking.
 
Day 3 Baton Rouge, LA
Baton Rouge, Louisiana’s state capital, was named over 300 years ago by French explorer Pierre Le Moyne d'Iberville. The city’s rich cultural traditions are reflected through its African-American and Caribbean influenced architecture, experienced through its fiery Creole and Cajun cuisine, and heard in its soulful Blues and Cajun style music. Baton Rouge is a wondrous city brimming with Southern hospitality.
 
Day 4 St. Francisville, LA
Established in 1809 and overlooking the Mississippi River, St. Francisville is a quaint Southern town that offers a glimpse into history. One of the largest shipping ports on the Mississippi River prior to the Civil War, St. Francisville is a small town with grand appeal. Experience this town’s rich history as you tour historic plantations, including the famous Rosedown and The Myrtles, or explore the captivating gardens in this area.
 
Day 5 Natchez, MS
Overlooking the Mississippi River, Natchez was first established as a French fort site in 1716, later becoming part of the United States as the first capital of Mississippi in 1817. Perched over 200 feet above the Mississippi River with 30-mile views along the river both north and south, the bluff of Natchez is a place to marvel in the beauty and grandeur of the river. A quaint Southern town rich in culture, history, and known for its abundance of antebellum architecture, Natchez offers true southern hospitality with the attractions of a great small city.
 
Day 6 Vicksburg, MS
Around every corner, U.S. history is alive in Vicksburg. This “Queen City of the Bluff” offers plenty of opportunities to take a step back in time. Civil war battlefields, century old churches, cotton fields, and restored train depots are just a few of the many intriguing landmarks that await your visit. Marvel in the beautiful antebellum-style homes and watch Vicksburg’s history come to life at the riverfront murals.
 
Day 7 Day of River Cruising
Join friends in the lounge or relax on your balcony as we cruise the Mississippi River from Vicksburg to Memphis.
 
Day 8 Memphis, TN
Excitement resonates as you reach America’s third-largest inland port, famous for blues, barbeque, and Elvis Presley's Graceland. Less-touted attractions, such as the Pink Palace and Mud Island’s River Walk, replicating 1,000 miles of Mississippi River history and geography along an intriguing six-block stroll, are just as intriguing. The Memphis-Arkansas Memorial Bridge creates a dramatic backdrop for it all. As you disembark, immerse yourself in the sights and sounds of one of the mid-South's most remarkable cities.

Day 9 Day of River Cruising
Grab a good book and curl up in one of our spacious lounges, or relax and enjoy the passing landscapes as we make our way up the Mississippi River from Memphis, TN to Columbus, KY.

Day 10 Columbus, KY
Relive the Civil War era in this historic town best known for its seizure by Confederate forces in September 1861. A large anchor chain was stretched from one side of the Mississippi River to Belmont, one of several events commemorated at Columbus-Belmont State Park. Learn about the Battle of Belmont at the park’s museum and bring home charming souvenirs from the site’s gift shop.

Day 11 Paducah, KY
Paducah, KY, became a major travel destination in 1991, when the National Quilt Museum opened its doors in the city. Every year, more than 40,000 quilting enthusiasts visit the Museum to see a wide variety of exhibits. For fans of art, Paducah’s LowerTown is home to a successful artist relocation program, where you can participate in creative workshops and discussions with professional artists.

Day 12 Day of River Cruising
Enjoy onboard experts sharing their knowledge of the history of the river and out nation as we cruise between Paducah and Cape Girardeau.

Day 13 Cape Girardeau, MO
Enjoy the charming features of this historic town that was once a French trading post and lively river port in the late 1800s. Today it boasts Civil War sites and a tranquil setting commemorating the Cherokee Trail of Tears. Marvel at the outdoor murals reflecting the area's rich heritage and enjoy shore excursions to Cape River Heritage Museum and the Red House Interpretive Center.

Day 14 Chester, IL
Chester is a beautiful region of Illinois located on the bluffs of the Mississippi River. This city has a diverse and storied history, beginning with the establishment of a ferry system by Jane Thomas in the early 1800s. Chester is home to Popeye's creator Elzie C. Segar and you may see the Sailor Man's likeness in the town's own six-foot-tall bronze metal statue 

Day 15 St. Louis, MO
Reflect upon the role St. Louis played in the opening of the American frontier as you cruise past the famed Gateway Arch Riverfront, the tallest man-made monument in the U.S. Get settled in and acquainted at a festive cocktail event with a welcome from the captain as you prepare for a trip down the Mississippi to the Ohio River, one of the most picturesque waterways in the country

Day 16 Hannibal, MO
Hannibal, “America’s Hometown,” is a place where you can rediscover adventures from Mark Twain’s era. Tom Sawyer and Huck Finn are alive in this charming Missouri town, where you can run your hand along Aunt Polly’s fence, explore Injun Joe’s Cave, and get reacquainted with one of the world’s most beloved authors. The downtown area is a thriving haven for artisans filled with wonderful and special shops unique to Hannibal. No matter what you choose to do, you will find this town to be very accommodating.

Day 17 Day of River Cruising
Reflect on the incredible history you've experience so far on your cruise and get ready for the final leg of the trip, where we explore the Upper Mississippi River together.

Day 18 Davenport, IA
Davenport is often described by newcomers and life-long residents alike as a lively, active city with a hometown feel. This vibrant city features the Legacy of John Deere, the largest agricultural exhibit in the world. Music enthusiasts will enjoy Davenport’s many music festivals, including the Mississippi Valley Blues Festival, The Mississippi Valley Fair, and the Bix Beiderbecke Memorial Jazz Festival, which is dedicated to native jazz musician Bix Beiderbecke.

Day 19 Dubuque, IA
Dubuque is among the oldest settlements west of the Mississippi River. Dubuque is overflowing with things to do and see. Take a ride on the Fenelon Place Elevator, the world’s shortest and steepest scenic railway or try your luck in one of Dubuque's state-of-the-art casinos. View colorful Victorian mansions, stroll through a whimsical downtown area, and visit the national Mississippi River Museum and Aquarium.

Day 20 La Crosse, WI
Step into 19th century America in La Crosse, located on the banks of three captivating rivers. La Crosse is home to Riverside Park, where you’ll enjoy beautiful gardens, an outdoor performance center, and inspiring sculptures.

Day 21 Red Wing, MN
Nestled among the scenic bluffs of the upper Mississippi River, Red Wing's beauty has inspired artisans, craftspeople and artists for over 150 years. Red Wing delivers a diverse blend of arts, entertainment and activities for your pleasure. Enjoy a show at the historic Sheldon Performing Arts Theatre or observe the beauty of nature at one of Red Wing’s 38 parks.

Day 22 St. Paul, MN
Disembark after breakfast. 
Tour Map
All This Included
This epic journey aboard the new American Eagle cruises the entire length of the Mississippi River from New Orleans, LA to St. Paul, MN. Visit 10 states in 22 days, even more than Huck Finn's famous trip down the Mississippi River, to experience a complete history of the western frontier.
  • Dining service, snacks and complimentary cocktail parties.
  • Entertainment aboard the ship.
  • Oversized staterooms – largest in industry.
  • Most with private balconies.
  • Flat screen satellite TV and DVD players in all staterooms.
  • Wireless internet access shipwide.
  • Hairdryers in all staterooms.
  • Individual climate control in all staterooms.
Accommodations on this Tour
Category A cabin onboard America
Notes
  • Cabin upgrades are available.
  • Itinerary is subject to change.
  • Fares do not include shore tours, gratuities, or port charges and fees.
  • Please ask your Vacations To Go travel counselor for more information.
Terms and Conditions

* The prices shown are U.S. dollars per person, based on double occupancy, and subject to availability. Prices quoted for land/cruise arrangements are subject to increase without notice. Once we have received your deposit, land/cruise prices are guaranteed. Air prices quoted via phone or email are subject to increase and are guaranteed only from the time that full payment is received. Also, air prices or air promotions mentioned on this site or on the phone do not include baggage fees imposed by airlines. Sorry, we are unable to offer air from countries other than the U.S. However, for those international customers who are able to arrange their own transportation to the trip origination city, we are able to offer the land/cruise portion of the package at the price quoted.



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