Day 1 St. Paul, MN
St. Paul is a thrilling place to begin your adventure on the Mississippi River. History buffs will enjoy a walking tour of Summit Avenue, which showcases gorgeous historic mansions built in the late 1800’s. St. Paul’s enchanting art galleries, world class museums, and entertaining stage performances will capture your imagination.
Day 2 Red Wing, MN
Nestled among the scenic bluffs of the upper Mississippi River, Red Wing's beauty has inspired artisans and craftspeople for over 150 years. Red Wing delivers a diverse blend of arts, entertainment, and activities for your pleasure. Enjoy a show at the historic Sheldon Performing Arts Theatre or observe the beauty of nature at one of Red Wing’s 38 parks.
Day 3 La Crosse, WI
Step into 19th-century America in La Crosse, located on the banks of three legendary rivers. Riverboats depart from the city’s Riverside Park which features international friendship gardens with landscape styles from around the world. Visit the Riverside Museum which traces the rich history of La Crosse or Dahl Auto Museum with an expansive collection restored classic cars. Explore Grandad Bluff Park with walking trails which offer spectacular views of the city.
Day 4 Dubuque, IA
A “Masterpiece on the Mississippi,” Dubuque is among the oldest settlements west of the river. Take a ride on the Fenelon Place Elevator, the world’s shortest and steepest scenic railway, or try your luck in one of Dubuque's state-of-the-art casinos. View colorful Victorian mansions, stroll through the bustling downtown area, or visit the national Mississippi River Museum and Aquarium.
Day 5 Davenport, IA
Voted one of the Most Livable Small Cities in America, Davenport is often described as a lively, active city with a hometown feel. The Legacy of John Deere, the largest agricultural exhibit in the world, resides here. Music enthusiasts will enjoy Davenport’s many festivals, including the Mississippi Valley Blues Festival, The Mississippi Valley Fair, and the Bix Beiderbecke Memorial Jazz Festival.
Day 6 Fort Madison, IA
Founded as an active military outpost in 1808, Fort Madison was one of three posts established by the U.S. Army to maintain control over the newly acquired Louisiana Territory. Today, Fort Madison offers visitors a vibrant cultural scene, bucolic landscapes, and an active agri-tourism industry which celebrates the American heartland. Explore its many historic districts, where you can admire the well-preserved Victorian and Post Renaissance architecture. Enjoy the area’s museums, unique boutiques, antique shops, as well as the local breweries and wineries.
Day 7 Hannibal, MO
Hannibal, “America’s Hometown,” is a place where you can rediscover adventures from Mark Twain’s era. Tom Sawyer and Huck Finn come to life in this charming Missouri town, where you can run your hand along Aunt Polly’s fence, explore Injun Joe’s Cave, and get reacquainted with one of the world’s most beloved authors. The downtown area is a thriving haven for artisans, filled with specialty shops unique to Hannibal.
Day 8 St. Louis, MO
St. Louis is often referred to as the “Gateway to the West.” Take in the Gateway Arch Riverfront, highlighted by the Gateway Arch, the largest man-made monument in the U.S. Enjoy St. Louis' many world-class attractions, including the Art Museum, Science Center, Anheuser-Busch Brewery, and the Missouri History Museum. End your day by relaxing at the Missouri Botanical Garden, one of the world’s most popular public gardens.
Day 9 Day of River Cruising
Curl up with a good book in one of our spacious lounges, or grab a pair of binoculars and enjoy the fall foliage as we make our way down the Mississippi River.
Day 10 Memphis, TN
Excitement resonates as you reach America’s third-largest inland port, famous for Blues, BBQ, and Elvis Presley's Graceland. The city has been at the forefront of several American cultural movements such as Civil Rights and Rock ‘n’ Roll. In fact, the city’s Beale Street is often called “America’s Most Iconic Street” due to its significance to our country’s history and contributions to the music industry.
Day 11 Day of River Cruising
Spend a beautiful day with friends in one of the ship's comfortable lounges as we explore the river from Memphis to Vicksburg.
Day 12 Vicksburg, MS
U.S. history is alive in Vicksburg. This “Queen City of the Bluff” offers plenty of opportunities to take a step back in time. Civil War battlefields, century old churches, cotton fields, and restored train depots are just a few of the many intriguing landmarks that await your visit. Marvel in the beautiful antebellum-style homes and learn about Vicksburg’s rich history as displayed on the riverfront murals.
Day 13 Natchez, MS
Settled in 1716, Natchez is rich in history and southern hospitality. Enjoy a guided exploration of this fascinating city which has retained its antebellum charm since its surrender during the Civil War. Visit Frogmore, a historic cotton plantation still in use today, or attend a special piano concert in the J. N. Stone music room.
Day 14 Baton Rouge, LA
Experience the wonder of Baton Rouge, Louisiana's capital and one of the most historic and unforgettable cities in the South. Known as the Red Stick, Baton Rouge has everything you would expect to find in a state capital, but with a down-home flavor that is part of its charm.
Day 15 New Orleans, LA
Welcome back to New Orleans, the birthplace of Jazz. Culture and art abound around every corner of this unique city. The open-air artist colony proudly displays local works on the iron fence in Jackson Square, while the city’s 45 museums carefully preserve its rich history. Stay an extra day or more to enjoy the famed French Quarter.
All This Included
Enjoy an epic 15-day journey on our Grand Heartland Cruise. This cruise on the Mississippi River travels from the northern reaches of St. Paul all the way down to the basin in New Orleans.
View the dramatic landscapes of the Upper Mississippi River which have long inspired artists, writers, and steamboat passengers. Visit Hannibal, the hometown of Mark Twain where the characters in his most popular works come to life. Immerse yourself in the culture of Memphis, the mid-South's most vibrant city, famous for Blues and BBQ.
As you journey down the river, hear stories about southern life on the plantation and tour historic Civil War sites led by our local area experts. On your final stop, New Orleans, enjoy privileged access to its vibrant music scene and the best in Cajun and Creole cuisine.
Just as it was in Mark Twain’s day, every cruise on the Mississippi River is unique due to fluctuating river conditions that can have an impact on our itinerary. The river has a mind of its own and our sailing schedules must adapt to it. This is part of the adventure and American Cruise Lines will always work to provide a seamless travel experience.
Dining service, snacks and complimentary cocktail parties.
Entertainment aboard the ship.
Gratuities aboard the ship.
Oversized staterooms – largest in industry.
Most with private balconies.
Flat screen satellite TV and DVD players in all staterooms.
Wireless internet access shipwide.
Hairdryers in all staterooms.
Individual climate control in all staterooms.
Accommodations on this Tour
Cruising: cabin onboard the America, American Harmony, or Queen of the Mississippi
Pre and Post Add-ons
Pre-Cruise Complimentary Package
Each Mississippi itinerary comes complete with a Complimentary Pre-Cruise Package, providing you with a seamless way to board the ship and explore the local area. Arrive the day before your scheduled cruise date and American Cruise Lines will handle the rest. The package includes a premium hotel stay, where you can enjoy the city at your leisure. On the morning of the cruise, meet in the hotel lobby after breakfast and we will transport you to the ship to begin your cruise. All luggage will be brought directly from the hotel and placed in your stateroom aboard the ship.
Pre-Cruise Packages must be reserved at least 30 days before your cruise date.
Cabin upgrades are available.
Itinerary is subject to change.
Fares do not include port charges of $440 per person.
Please ask your Vacations To Go counselor for more information.
Terms and Conditions
The prices shown are U.S. dollars per person, based on double occupancy, and subject to availability. Prices quoted for land/cruise arrangements are subject to increase without notice. Once we have received your deposit, land/cruise prices are guaranteed. Air prices quoted via phone or email are subject to increase and are guaranteed only from the time that full payment is received. Also, air prices or air promotions mentioned on this site or on the phone do not include baggage fees imposed by airlines. Sorry, we are unable to offer air from countries other than the U.S. However, for those international customers who are able to arrange their own transportation to the trip origination city, we are able to offer the land/cruise portion of the package at the price quoted.