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Complete Mississippi River Cruise

22 days with American Cruise Lines  Rating: Deluxe

Book this River Cruise Now and Save!


  • Save $1,000 per couple off this cruise. Click here for eligible departures.
  • Save $400 per couple off American Cruise Lines departures when you book nine months in advance. Click here for eligible departures.
  • Receive one free hotel night before your cruise with American Cruise Lines, plus transfers to your ship on the day of departure when you book one month in advance. Click here for eligible departures.
  • Receive free shore excursions on this river cruise. Click here for eligible departures.
  • Enjoy a free open-bar cocktail hour every evening before dinner. Click here for eligible departures.

Offers subject to change or withdrawal, availability is limited. Some discounts are not combinable.

River Cruise Itinerary
Day 1 New Orleans, LA
New Orleans is commonly referred to as the birthplace of Jazz. There is something for everyone in this historic city where art and culture prevail. The open-air artist colony proudly displays local works on the iron fence in Jackson Square, while the city’s 45 museums carefully preserve its past. Consider staying an extra day or night to enjoy this lively city.
 
Day 2 Oak Alley, LA
Once serving as an antebellum sugar cane plantation, Oak Alley Plantation is rightfully named after its most distinguishing feature, a canopy of 300-year-old oak trees that form a quarter-mile path leading to the Mississippi River. Restored to its 19th-century grandeur, this classic Greek Revival-style antebellum mansion is simply breathtaking.
 
Day 3 Houmas House, LA
The historic Houmas House takes you back to the pre-Civil War era of stately mansions and expansive plantations. Featuring over 38 acres of lush gardens, ponds, and ancient oak trees, this shore excursion is rich in beauty and history. Enduring floods, war, and the Great Depression, Houmas House underwent a renovation in 1940 and today offers a detailed look into the legacy of the South.
 
Day 4 Baton Rouge, LA
Experience the wonder of Baton Rouge, Louisiana's capital, and one of the most historic and unforgettable cities in the South. Known as the Red Stick, Baton Rouge has everything you would expect to find in a state capital, but with a down-home flavor that is part of its charm. 
 
Day 5 St. Francisville, LA
Established in 1809, St. Francisville is a quaint southern town overlooking the Mississippi River. One of the largest shipping ports on the Mississippi River prior to the Civil War, St. Francisville is a small town with appeal. Experience the town’s rich history as you tour historic plantations, including the famous Rosedown, or explore the areas' captivating gardens.
 
Day 6 Natchez, MS
Settled in 1716, Natchez is rich in history and southern hospitality. Enjoy a guided exploration of this fascinating city which has retained its antebellum charm since its surrender during the Civil War. Visit Frogmore, a historic cotton plantation still in use today, or attend a special piano concert in the J. N. Stone music room.
 
Day 7 Vicksburg, MS
U.S. history is alive in Vicksburg. This “Queen City of the Bluff” offers plenty of opportunities to take a step back in time. Civil War battlefields, century-old churches, cotton fields, and restored train depots are just a few of the many intriguing landmarks that await your visit. Marvel in the beautiful antebellum-style homes and learn about  Vicksburg’s rich history as displayed on the riverfront murals.
 
Day 8 Greenville, MS
Known as the Heart and Soul of the Mississippi Delta, the city of Greenville offers visitors insight into traditional southern living. Enjoy a relaxing trip through the historic sites of the largest city in Mississippi, including Cotton Row, the Mount Holly Plantation, and the Weatherbee House.
 
Day 9 Memphis, TN
Excitement resonates as you reach America’s third-largest inland port, famous for Blues, BBQ, and Elvis Presley's Graceland. The city has been at the forefront of several American cultural movements such as Civil Rights and Rock ‘n’ Roll. In fact, the city’s Beale Street is often called “America’s Most Iconic Street” due to its significance to our country’s history and contributions to the music industry. 
 
Day 10 New Madrid, MO
Originally founded in 1776 by Spanish Governor Esteban Rodriguez, early settlers of New Madrid were required to become citizens of Spain in order to reside here. Today, New Madrid is a living monument to early American history with sites including the Kochtitsky Home, the Trail of Tears, and Veterans Park.
 
Day 11 Cape Girardeau, MO
Enjoy the charming features of this historic town that was a French trading post and lively river port in the late 1800s. Today it boasts Civil War sites and a tranquil setting commemorating the Cherokee Trail of Tears. Marvel at the outdoor murals reflecting the area's rich heritage and enjoy shore excursions to Crisp Museum and the Old Vincent Church.
 
Day 12 Chester, IL
Chester is a beautiful region of Illinois located on the bluffs of the Mississippi River, with a diverse and storied history. Chester is also home to Popeye's creator Elzie C. Segar; you may see the sailor man's likeness in the town's six-foot-tall bronze metal statue.
 
Day 13 St. Louis, MO
St. Louis is often referred to as the “Gateway to the West.” Take in the Gateway Arch Riverfront, highlighted by the Gateway Arch, the largest man-made monument in the U.S. Enjoy St. Louis' many world-class attractions, including the Art Museum, Science Center, Anheuser-Busch Brewery, and the Missouri History Museum. End your day by relaxing at the Missouri Botanical Garden, one of the world’s most popular public gardens.
 
Day 14 Day of River Cruising
Curl up with a good book in one of our spacious lounges. Or relax on the sun deck and enjoy the passing landscapes as we make our way along the Mississippi River from St. Louis to Hannibal.
 
Day 15 Hannibal, MO
Discover Hannibal, “America’s Hometown,” and the inspiration behind many of Mark Twain’s literary characters. Tom Sawyer and Huck Finn come to life in this charming Missouri town, where you can run your hand along Aunt Polly’s fence, explore Injun Joe’s Cave, and get reacquainted with one of the world’s most beloved authors. The downtown area is a thriving haven for artisans, filled with specialty shops unique to Hannibal.
 
Day 16 Fort Madison, IA
Founded as an active military outpost in 1808, Fort Madison was one of three posts established by the U.S. Army to maintain control over the newly acquired Louisiana Territory. Today, Fort Madison offers visitors a vibrant cultural scene, bucolic landscapes, and an active agri-tourism industry which celebrates the American heartland. Explore its many historic districts, where you can admire the well-preserved Victorian and Post Renaissance architecture. Enjoy the area’s museums, unique boutiques, antique shops, as well as the local breweries and wineries.
 
Day 17 Davenport, IA
Davenport is often described as a lively place with a hometown feel. The Legacy of John Deere, the largest agricultural exhibit in the world, takes place here. Music enthusiasts will enjoy Davenport’s many music festivals, including the Mississippi Valley Blues Festival, The Mississippi Valley Fair, and the Bix Beiderbecke Memorial Jazz Festival, which is dedicated to native Jazz musician Bix Beiderbecke.
 
Day 18 Dubuque, IA
Dubuque is among the oldest settlements west of the Mississippi River. Take a ride on the Fenelon Place Elevator, the world’s shortest and steepest scenic railway or try your luck in one of Dubuque's state-of-the-art casinos. View colorful Victorian mansions, stroll through a whimsical downtown area, and visit the National Mississippi River Museum & Aquarium.
 
Day 19 Day of River Cruising
Reflect on the incredible journey you have experienced so far and get ready for the final leg of the trip, cruising the Upper Mississippi River.
 
Day 20 La Crosse, WI
Step into 19th-century America in La Crosse, located on the banks of three legendary rivers. Riverboats depart from the city’s Riverside Park which features international friendship gardens with landscape styles from around the world. Visit the Riverside Museum which traces the rich history of La Crosse or Dahl Auto Museum with an expansive collection restored classic cars. Explore Grandad Bluff Park with walking trails which offer spectacular views of the city.  
 
Day 21 Red Wing, MN
Nestled among the scenic bluffs of the Upper Mississippi River, Red Wing's beauty has inspired craftsmen and artisans for over 150 years. Red Wing offers a diverse blend of arts, entertainment, and activities. Enjoy a show at the historic Sheldon Performing Arts Theatre or observe the beauty of nature at one of Red Wing’s 38 parks.
 
Day 22 St. Paul, MN
St. Paul is an exciting place to end your adventure on the Mississippi River. History buffs will enjoy a walking tour of Summit Avenue, which showcases gorgeous historic mansions built in the late 1800’s. St. Paul’s enchanting art galleries, world-class museums, and entertaining stage performances will capture your imagination. End the day by visiting Mounds Park, where visitors are treated to a beautiful panoramic view of the city.
Tour Map
All This Included
This epic journey aboard the new American Eagle cruises the entire length of the Mississippi River from New Orleans, LA to St. Paul, MN. Visit 10 states in 22 days, even more than Huck Finn's famous trip down the Mississippi River, to experience a complete history of the western frontier.
  • Dining service, snacks and complimentary cocktail parties.
  • Entertainment aboard the ship.
  • Gratuities aboard the ship.
  • Oversized staterooms – largest in industry.
  • Most with private balconies.
  • Flat screen satellite TV and DVD players in all staterooms.
  • Wireless internet access shipwide.
  • Hairdryers in all staterooms.
  • Individual climate control in all staterooms.
Accommodations on this Tour
Category A cabin onboard American Harmony or American Jazz
Pre and Post Add-ons
Pre-Cruise Complimentary Package
Each Mississippi itinerary comes complete with a Complimentary Pre-Cruise Package, providing you with a seamless way to board the ship and explore the local area. Arrive the day before your scheduled cruise date and American Cruise Lines will handle the rest. The package includes a premium hotel stay, where you can enjoy the city at your leisure. On the morning of the cruise, meet in the hotel lobby after breakfast and we will transport you to the ship to begin your cruise. All luggage will be brought directly from the hotel and placed in your stateroom aboard the ship.
 
Pre-Cruise Packages must be reserved at least 30 days before your cruise date.

Notes
  • Cabin upgrades are available.
  • Itinerary is subject to change.
  • Fares do not include port charges.
  • Please ask your Vacations To Go travel counselor for more information.
Terms and Conditions

* The prices shown are U.S. dollars per person, based on double occupancy, and subject to availability. Prices quoted for land/cruise arrangements are subject to increase without notice. Once we have received your deposit, land/cruise prices are guaranteed. Air prices quoted via phone or email are subject to increase and are guaranteed only from the time that full payment is received. Also, air prices or air promotions mentioned on this site or on the phone do not include baggage fees imposed by airlines. Sorry, we are unable to offer air from countries other than the U.S. However, for those international customers who are able to arrange their own transportation to the trip origination city, we are able to offer the land/cruise portion of the package at the price quoted.



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