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Ohio River Cruise
(Pittsburgh to St. Louis)

11 days with American Cruise Lines  Rating: Deluxe

Book this River Cruise Now and Save!

  • Save $1,000 to $2,000 per couple off this cruise. Click here for eligible departures.
  • Receive one free hotel night before your cruise with American Cruise Lines, plus transfers to your ship on the day of departure when you book one month in advance. Click here for eligible departures.
  • Save $400 per couple off American Cruise Lines departures when you book nine months in advance. Click here for eligible departures.
  • Receive free shore excursions on this river cruise. Click here for eligible departures.
  • Enjoy a free open-bar cocktail hour every evening before dinner. Click here for eligible departures.

Offers subject to change or withdrawal, availability is limited. Some discounts are not combinable.

River Cruise Itinerary
Day 1 Pittsburgh, PA
Begin your journey in "steel city," Pittsburgh. Long known for steel manufacturing, Pittsburgh was an essential stop along the Ohio River for national and international commerce, making it a wealthy town in the 18th and 19th centuries.
Day 2 Marietta, OH
The second-largest city in the Parkersburg-Marietta-Vienna Metropolitan area, Marietta was named in honor of Marie Antoinette. During the 18th and 19th century, the town experienced economic prosperity, as its location on the Ohio River made it an attractive stop for commercial steamboats, as well as travelers.
Day 3 Maysville, KY
Maysville is a quaint town with a rich history. An important stop on the Underground Railroad, Maysville was host to Harriet Beecher Stowe in 1883. Your stop will include idyllic country scenery and the native sounds of original bluegrass country music.
Day 4 Cincinnati, OH
Enjoy a visit to Cincinnati, a vibrant city and cultural center which boasts two major sports franchises, a zoo and botanical garden, and numerous theaters and museums. Stroll along its picturesque streets, abounding in eclectic architecture and shop at the famous Findlay Market, a longtime gathering place for vendors to sell local goods, meats, and fresh produce.
Day 5 Louisville, KY
Named after King Louis XVI of France, Kentucky was originally a part of Virginia, becoming the 15th state to join the Union in 1792. Louisville is best known for the famed Kentucky Derby, the first leg of the Triple Crown of Thoroughbred Racing, and the oldest continuously held horse race in the country.
Discover why Louisville is often referred to as either the northernmost southern city or the southernmost northern city in the United States.
Day 6 Louisville, KY
Spend another day in Kentucky, known as the "Bluegrass State," due to the bluegrass found in many of its pastures because of the fertile soil. Admire the city's architecture which is a blend of old and new. Explore the Old Louisville neighborhood, the largest historic preservation district in the U.S., solely featuring Victorian homes and buildings.
Day 7 Henderson, KY
You won’t miss the presence of the notable resident, John James Audubon, whose “Birds of America” paintings are recreated as bronze statues throughout Henderson. Named after President Washington’s home on the Potomac, this bucolic river town is steeped in fascinating lore. Let our expert guide lead you on a tour of our famous first President's historic home and grounds.
Day 8 Paducah, KY
Residing at the confluence of the Tennessee River and the Ohio River, Paducah will make you feel as if you stepped back in time. As you walk the streets of this Chickasaw village site, discover Paducah’s rich history. View the Wall-to-Wall Mural Program, a collection of over 50 murals that covers a number of subjects including Native American history, the Civil War, and area landmarks such as the Old Carnegie Library.
Day 9 Cape Girardeau, MO
Enjoy the charming features of this historic town that in the late 1800s was a French trading post and lively river port. Today, it boasts Civil War sites and a tranquil setting commemorating the Cherokee Trail of Tears. Marvel at the outdoor murals reflecting the area's rich heritage and enjoy shore excursions to Cape River Heritage Museum and the Red House Interpretive Center.
Day 10 St. Louis, MO
St. Louis is sure to win you over. Admire the scenic riverfront, highlighted by the majestic Gateway Arch, the largest man-made monument in the U.S. Enjoy St. Louis’ many world-class attractions, including the Art Museum, Science Center, and the Missouri History Museum. End your day at the Missouri Botanical Garden, one of the world’s most popular public gardens.
Day 11 St. Louis, MO
Departure day. We recommend you spend an extra day to explore this vibrant city. Visit the Missouri Botanical Garden, one of the world’s most popular public gardens.
Tour Map
All This Included
Experience the picturesque waterways of the Mississippi and Ohio Rivers aboard the magnificent Queen of the Mississippi. Step back in time to the grand era of paddlewheels as we explore the heartland of America. While the churn of the paddlewheel blends with the sounds of the river, you’ll rediscover the America of the pioneers, boundless optimism and unlimited possibilities.
  • Dining service, snacks and complimentary cocktail parties.
  • Entertainment aboard the ship.
  • Gratuities aboard the ship.
  • Oversized staterooms – largest in industry.
  • Most with private balconies.
  • Flat screen satellite TV and DVD players in all staterooms.
  • Wireless internet access shipwide.
  • Hairdryers in all staterooms.
  • Individual climate control in all staterooms.
Accommodations on this Tour
Category A cabin onboard the Queen of the Mississippi

  • Cabin upgrades are available.
  • Itinerary is subject to change.
  • Fares do not include port charges of $330 per person.
  • Please ask your Vacations To Go counselor for more information.
Terms and Conditions

* The prices shown are U.S. dollars per person, based on double occupancy, and subject to availability. Prices quoted for land/cruise arrangements are subject to increase without notice. Once we have received your deposit, land/cruise prices are guaranteed. Air prices quoted via phone or email are subject to increase and are guaranteed only from the time that full payment is received. Also, air prices or air promotions mentioned on this site or on the phone do not include baggage fees imposed by airlines. Sorry, we are unable to offer air from countries other than the U.S. However, for those international customers who are able to arrange their own transportation to the trip origination city, we are able to offer the land/cruise portion of the package at the price quoted.

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